Agyekum began performing as Dr Cryme (Creative Rhymes You Most Enjoy) since high school as a rapper and appeared on a popular rap competition "Kasahare Level" on Adom FM; a radio platform that gave chance to upcoming rappers to heard. Due to his rap style, he was referred to as “Tema Eminem” as it's believe he took inspirations from American Rapper Eminem.

In June 2010, where he was officially presented by E-Jam Records at a debut party at the Bacardi Sports Bar in Tema.

His first major hit single was "Kill Me Shy", released off of his Finally Finally album in June 2011.

"Kill Me Shy" went on to become a number one hit for two quarters in 2011.

Dr Cryme's second major single, "1Step 2Back" was released on August 2012.

Dr. Cryme Darlington has shared the stage with Spliff Star, Busta Rhymes, Rick Ross and more.

In September 2011 Dr Cryme won the Golden Heart Award in the UK organized by Dzifa Gray who happens to be the founder, Producer and director of the Titi Gray Talk Show on BEN TV, (Sky Channel 184), airing every Saturday at 7PM.

He was rated the most bankable young artiste for 2011 by the GH Review newspaper.

Subsequently, in 2012, Dr Cryme (also appearing as D-Cryme) won the "Hiplife Song of Year" award, and gained nominations for "Best New Artist of the Year", "Most Popular Song of the Year" "Hiplife/Hip Hop Artiste of the Year" and "Song Writer of the year" at the Ghana Music Awards

Agyekum was highly criticized for his inability to produce a major hit after "kill me shy" in 2013 and 2014. He proved critics wrong in 2015 after releasing "Koko Sakora" which features Sarkodie

Recently, "Koko Sakora" has been on top of the music charts around Ghana.