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Polyuria Is The Cause Of Diabetes Complications   
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The original meaning of the Greek source of the word Diabetes was “siphon”, because people with the condition “pass water like a siphon”. The “water” passed was either honey –flavoured or flavourless; hence the Latin words “mellitus” (from mel; honey) and “Insipidus” (flavourless, tasteless.) So “passing water like siphon” is the event; mellitus and insipidus merely descriptions of the flavour of the water.

“Passing water like siphon” is another way of saying “increased frequency in urination and volume of urine passed”. This is the definition of polyuria.

Apart from nuisance value, polyuria has been ignored as having no further influence on the progress of the condition. These days, when the word “diabetes” is heard, it is immediately associated with diabetes mellitus – a condition of high glucose concentration in the blood plasma. Subsequently, all research and clinical efforts are undertaken with this meaning in mind.

It is no wonder that all micro and macro vascular complications associated with the condition are also described as “diabetes complications”.

It is the contention here that the long-term chronic complications like blindness, kidney failure, heart disease, stroke and skin sores that do not heal easily, may have other explanations not connected with blood plasma glucose at all.

Data from Thornalley et al.

In table 1 is displayed the essential findings of a study by Thornalley and his associates on the behaviour of thiamine in blood plasma of diabetes patients. They did this by comparing diabetic patients and healthy subjects in a 24-hour period. Information on factors such as, the racial mix of the experimental subjects; whether the subjects fasted or had regular 3 meals for the day; drank water or other liquid during the day; were confined to bed or were allowed to engage in their normal daily activities, etc; during the period were lacking in the report.

In spite of this, the findings are significant because they demonstrate that polyuria reduces plasma concentration of water-soluble thiamine to 25 per cent of the concentration required by non-diabetic persons to sustain full 24-hour vasodilatation in the microcirculation. This has given rise to a new theory for the cause of long-term chronic diabetes complications.

Even though Thornalley al alt. did not use the term “polyuria” to describe their work, this summary clearly shows the effect of polyuria on the concentration of thiamine in the blood plasma of diabetes patients.

These findings have been used to propose a new theory on diabetes complications. In fact, it challenges the prevailing paradigm which postulates that diabetes complications are caused by high blood plasma glucose concentration.

New theory

If the experimental findings are applied to daily, diet-sourced, vitamin B – including vasodilators niacin and thiamine – the following conclusions can be drawn.

• Polyuria reduces the total concentration of thiamine and niacin to about half of the concentration needed by a healthy non-diabetic person to sustain full 24-hour vasodilatation in the microcirculation. (This assumes that niacin and thiamine act in synergy.)

• During the period of reduced concentration of the vasodilators, there is vasoconstriction in the microcirculation.

• The vasoconstriction impacts adversely on the exchange of gases, nutrients and particles between blood and tissue;

• Resulting in daily tissue damage.

• Over time (five-40 years) the cumulative tissue damage results in organ dysfunction – the so-called diabetes complications.

Deductions from Theory

From the postulates of the theory, the following deductions can be made:

• Development of diabetes complications is independent of blood plasma glucose concentration.

• Diabetes complications develop only in organs with microcirculation, e.g. the eye; kidney, heart, brain (nervous system) and skin. This is also the clinical experience.

• All complications in these organs are initiated simultaneously in the patient at the onset of diabetes mellitus, but symptoms of DC do not manifest at the same time in all susceptible organs.

• Any therapy that cures any manifested symptom in any one organ, must cure manifested symptoms in all of the susceptible organs.

• Breaking or disrupting the chain of events outlined in 1. Will stop or prevent tissue damage.

Flowing from these deductions the following hypothesis can be made.


If a diabetes patient is given a daily supplementation of minimum concentration of vasodilator(s) to sustain full 24-hour vasodilatation in the microcirculation tissue damage will stop and organs allowed to heal naturally.

4. Experiment

A tablet, named FENOMIN, containing nicotinamide, 15.0mg; thiamine hydrochloride, 12.5mg; calcium-d-pantothenate, 11.0mg, was prepared and, in an open trial, given to patients to ingest one a day before bed.

As the tissue damage occurred daily, there was no end time. The patients used the tablets till they saw or felt improvement in their condition. The self-reports made to researchers are shown in table 2.


The first row shows the methods used by patients to control their blood glucose levels. The first column is the nature of complication the patients reportedly suffered from.

The second column is the special case where the patients were not diabetic patients, but suffered symptoms similar to that of diabetic patients. When questioned they all reported “urinating too much, including waking up more that twice in the night to urinate” and also that they came to know about “fenomin” tablets through recommendation by friends who had been cured of symptoms similar to their own.

The table shows that the cure of early stage symptoms of diabetes complications by the therapy is independent of blood plasma glucose concentration. Also, the symptoms cured affect all the susceptible organs, except the brain and the heart. No conclusions could be drawn about these organs as these organs do not show early symptoms of stroke or heart failure.

The theory recommends that patients continue to use the tablets as long as the diabetic condition remained, however, a large number of patients stopped using the tablets as soon as their ailing condition improved/cured. Some, who stopped for sometime, came back on the tablets after six months to a year when they felt recurrence of their symptoms or new symptoms of diabetes complications affecting some other organ, manifested.

Some patients, including the author, have used the tablet regularly without break for the past seven/eight years and have not had any new symptoms or recurrence of the initial symptoms they had before using the tablets. They have not reported any side effects from the use of the tablets.

No effort has been made at this stage to explain the nature of the tissue damage or the mechanism of the healing processes. These will be the subjects of future studies.


These initial results have demonstrated direct connection between polyuria and long-term chronic diabetes complications. The hypothesis that the polyuria-induced vasodilator deficiency causes tissue damage has also been validated.


The cure and prevention of long-term chronic diabetes complications affecting the eye, kidney and the skin, by a single, cheap, easy to manufacture therapy, is significant.

The ingredients are well characterised and known to have no side effects. This is a promising lead in the research for cure and prevention of long-term chronic diabetes complications.

The new paradigm and its implications on the cure and prevention of long-term chronic diabetes complications warrant further investigations.

Source: Daily Guide

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