African champions Zambia are already struggling in their bid to reach the 2014 World Cup, after losing their opening qualifier 2-0 in Sudan.
The Chipolopolo host a Ghana team on Saturday, who will be out for revenge having lost to Zambia in the semi-finals of this year's Africa Cup of Nations.
Elsewhere, South Africa will be looking to bounce back after coach Pitso Mosimane lost his job following the 1-1 home draw against Ethiopia.