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Chris Brown is angry, feeling like he was stabbed in the back by Quavo from Migos ... a man he thought was a good friend until he started dating Karrueche Tran.

Our CB sources say ... Chris had both a business and personal relationship with Quavo ... inviting him to his home, collaborating on songs before Migos hit big, and supporting the group by attending multiple promotional parties.

Chris is livid that he actually helped promote Migos' recent hit album, "Culture," at the same time Quavo was secretly seeing his ex-girlfriend.