A malaria vaccine has proved to be 77% effective in early trials and could be a major breakthrough against the disease, say its developers from the University of Oxford.
Malaria kills more than 400,000 people a year, mostly children in sub-Saharan Africa.
But despite many vaccines being trialled over the years, none has met the required target for success.
The researchers say the vaccine could have a major public health impact.
When trialled in 450 children in Burkina Faso, the vaccine was found to be safe, and showed "high-level efficacy" over 12 months of follow-up.
Larger trials in nearly 5,000 children between the ages of five months and three years will now be carried out across four African countries, to confirm the findings.
Malaria is a life-threatening disease caused by parasites that are transmitted to people through mosquito bites. Although preventable and curable, the World Health Organization estimates there were 229 million cases worldwide in 2019 and 409,000 deaths.
The illness starts with symptoms such as fever, headaches and chills and, without treatment, `can progress quickly to severe illness and often death.
'Major health impact'
Adrian Hill, director of the Jenner Institute and professor of vaccinology at the University of Oxford, and co-author of the paper, said he believed the vaccine was the first to reach the World Health Organization's goal of at least 75% efficacy. The most effective malaria vaccine to date had only shown 55% efficacy in trials on African children.
The trials of this malaria vaccine started in 2019, long before coronavirus appeared - and the Oxford team developed its Covid vaccine on the strength of its research into malaria, Prof Hill said.
He said a malaria vaccine had taken much longer to come to fruition because there are thousands of genes in malaria compared to around a dozen in coronavirus, and a very high immune response is needed to fight off the disease.
"That's a real technical challenge," he said. "The vast majority of vaccines haven't worked because it's very difficult." However, Prof Hill said the trial results mean the vaccine "has the potential to have a major public health impact".
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